| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-871 | |
| Phytochemical name or plant extracts | Mansorin-C | |
| PMID | 29701706 | |
| Literature evidence | Mansorin-B and mansonone-G were found to inhibit the P-gp attached ATPase subunit. | |
| IUPAC name | 4,8,12-trimethyl-2,6-dioxatricyclo[7.3.1.05,13]trideca-1(12),4,9(13),10-tetraen-3-one | |
| Phytochemicals’ class or type of plant extracts | Coumarin | |
| Source of phytochemicals or plant Extracts | Mansonia gagei | |
| Geographical availability | Laos, Myanmar, Thailand | |
| Plant parts | Heartwood | |
| Other cancers | Breast cancer, Cervical cancer, Colorectal cancer, Liver cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 3.1 µM against MCF-7 | |
| Potency | Other compounds (mansorin-A, mansorin-B and mansorin-C) showed apparently low IC50s (2.1 μM, 5.0 μM and 3.1 μM, respectively) with very high resistance (R-values were higher than 70%) | |
| Cell line/ mice model | MCF-7, HepG2, HCT-116, HeLa | |
| Additional information | Mansorin-II, mansorin-B, mansorin-C and mansorin-I significantly increased cellular internalization of doxorubicin (P-gp probe) and significantly increased its intracellular concentration from 5.37 ± 0.17 nmole/cell to 5.78 ± 0.19 nmole/cell, 5.55 ± 0.13 nmole/cell, 5.8 ± 0.14 nmole/cell and 5.78 ± 0.19 nmole/cell, respectively. | |
| PubChem ID | 5275543 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:824303-1 | |
| Safety | NA |