| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-870 | |
| Phytochemical name or plant extracts | Mansorin-B | |
| PMID | 29701706 | |
| Literature evidence | Mansorin-B and mansonone-G were found to inhibit the P-gp attached ATPase subunit. | |
| IUPAC name | 6-hydroxy-3,8-dimethyl-5-propan-2-ylchromen-2-one | |
| Phytochemicals’ class or type of plant extracts | Coumarin | |
| Source of phytochemicals or plant Extracts | Mansonia gagei | |
| Geographical availability | Laos, Myanmar, Thailand | |
| Plant parts | Heartwood | |
| Other cancers | Breast cancer, Cervical cancer, Colorectal cancer, Liver cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 5.0 µM against MCF-7 | |
| Potency | Other compounds (mansorin-A, mansorin-B and mansorin-C) showed apparently low IC50s (2.1 μM, 5.0 μM and 3.1 μM, respectively) with very high resistance (R-values were higher than 70%) | |
| Cell line/ mice model | MCF-7, HepG2, HCT-116, HeLa | |
| Additional information | Only mansorin-B and mansonone-G showed pure ATPase inhibitory effects with 155.6% and 137.0% more remaining ATP concentration, respectively | |
| PubChem ID | 636576 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:824303-1 | |
| Safety | NA |