| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1139 | |
| Phytochemical name or plant extracts | Mango polyphenolics | |
| PMID | 26194618 | |
| Literature evidence | In summary, mango polyphenolics have a chemotherapeutic potential against breast cancer that at least in part is mediated through the PI3K/AKT pathway and miR-126. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Polyphenol | |
| Source of phytochemicals or plant Extracts | Mangifera indica | |
| Geographical availability | Assam, Belize, China South-Central, East Himalaya, Myanmar, Thailand | |
| Plant parts | Mango pulp | |
| Other cancers | Breast cancer | |
| Target gene or protein | PI3K, AKT, HIF-1α, VEGF mRNA, pAKT, AKT, pPI3K (p85), VEGF, NF-κB , NF-κB (p65), PARP | |
| Gene or Protein evidence | Mango polyphenolics suppressed the expression of PI3K, AKT, hypoxia inducible factor-1α, and vascular endothelial growth factor (VEGF) mRNA, and pAKT, AKT, pPI3K (p85), VEGF and nuclear factor-kappa B protein levels. In addition, mango reduced the expression of nuclear factor-kappa B (p65), pAKT, pPI3K, mammalian target of rapamycin, hypoxia inducible factor-1α, and VEGF protein in athymic nude mice. All fractions showed bioactivity in PPAR activation assays, but quantitative responses showed marked fruit-to-fruit variability, highlighting the need to bulk fruit prior to extraction for activity-guided fractionation of bioactive components. | |
| Target pathways | In summary, mango polyphenolics have a chemotherapeutic potential against breast cancer that at least in part is mediated through the PI3K/AKT pathway and miR-126. | |
| IC50 | NA | |
| Potency | In vitro findings showed cytotoxic effects of mango polyphenolics in BT474 breast cancer cells within a concentration range of 2.5 to 20 mg/L gallic acid equivalents. | |
| Cell line/ mice model | BT-474, xenografts in mice | |
| Additional information | A screening for miRNA expression changes confirmed that mango polyphenolics modulated the expression of cancer-associated miRNAs including miR-126 in the xenografted tumors. | |
| PubChem ID | NA | |
| Additional PMIDs | 31844767 33553895 34836251 30034503 21420233 24962691 25664859 26194618 25940566 25887035 21535682 25881293 29859842 27951515 31544171 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:69913-1 | |
| Safety | NA |