| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1352 | |
| Phytochemical name or plant extracts | Mango kernel extract | |
| PMID | 25664859 | |
| Literature evidence | The changes induced in the MCF-7 cells by mango kernel extract treatment suggest that the extract can induce cancer cell apoptosis, likely via the activation of oxidative stress. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Mangifera indica | |
| Geographical availability | Assam, Belize, China South-Central, East Himalaya, Myanmar, Thailand | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, cyt-c, MDA, p53, Bcl-2 | |
| Gene or Protein evidence | This study showed that mango kernel extract was able to increase expression of markers of apoptosis, Bax, cytochrome c, MDA, p53, ROS and caspases in breast cancer cells. Concomitantly, the extract also decreased pro-survival factors, GSH and Bcl-2 in the cancer cells, providing additional evidence that the mango kernel extract has anticancer properties. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MDA-MB-231, MCF-7 | |
| Additional information | The changes induced in the MCF-7 cells by mango kernel extract treatment suggest that the extract can induce cancer cell apoptosis, likely via the activation of oxidative stress. | |
| PubChem ID | NA | |
| Additional PMIDs | 25881293 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:69913-1 | |
| Safety | NA |