| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-81 | |
| Phytochemical name or plant extracts | Mangiferin | |
| PMID | 23707762 | |
| Literature evidence | Although mangiferin which is a naturally occurring glucosylxanthone has exhibited promising anticancer activities, the detailed molecular mechanism of mangiferin on cancers still remains enigmatic. | |
| IUPAC name | 1,3,6,7-tetrahydroxy-2-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]xanthen-9-one | |
| Phytochemicals’ class or type of plant extracts | Xanthone | |
| Source of phytochemicals or plant Extracts | Mangifera indica | |
| Geographical availability | Assam, Belize, China South-Central, East Himalaya, Myanmar, Thailand | |
| Plant parts | Bark | |
| Other cancers | Breast cancer | |
| Target gene or protein | MMP7, MMP9, Vimentin, E-cadherin, β-catenin, NF-κB, P-gp | |
| Gene or Protein evidence | Consistent with these findings in vitro, the antitumor potential was also verified in mangiferin-treated MDA-MB-231 xenograft mice where significantly decreased tumor volume, weight and proliferation, and increased apoptosis were obtained, with lower expression of MMP-7 and -9, vimentin and active β-catenin, and higher expression of E-cadherin. At the molecular level, mangiferin and gallic acid both inhibit classical NFκB activation by IKKα/β kinases, which results in impaired IκB degradation, NFκB translocation and NFκB/DNA binding. The mRNA expression analysis of P-gp, MRP1 and BCRP showed that mangiferin had inhibitory effects on P-gp but no effects on MRP1 and BCRP. | |
| Target pathways | β-catenin signaling pathway | |
| IC50 | 298.6 μM against MDA-MB-231 273.8 μM against BT-549 | |
| Potency | Taken together, our study suggests that mangiferin might be used as an effective chemopreventive agent against breast cancer. | |
| Cell line/ mice model | MDA-MB-231 xenograft mice, MCF-7 | |
| Additional information | Subsequent experiments showed that inhibiting β-catenin pathway might play a central role in mangiferin-induced anticancer activity through modulation of MMP-7 and -9, and EMT. | |
| PubChem ID | 5281647 | |
| Additional PMIDs | 24641381 21420233 25940566 23707762 29967581 31484532 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:69913-1 | |
| Safety | NA |