| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-714 | |
| Phytochemical name or plant extracts | Mangifera indica peels extract | |
| PMID | 27585256 | |
| Literature evidence | Aromatase inhibitors (AIs) provide novel approaches to the adjuvant therapy for postmenopausal women with estrogen-receptor-positive (ER+) breast cancers. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Mangifera indica | |
| Geographical availability | Assam, Belize, China South-Central, East Himalaya, Myanmar, Thailand | |
| Plant parts | Peels | |
| Other cancers | Breast cancer | |
| Target gene or protein | Aromatase | |
| Gene or Protein evidence | Also, MPE may be has the potential to be used as a tissue-specific aromatase inhibitor (selective aromatase inhibitor) and it may be promising to develop a new therapeutic agent against ER+ breast cancer. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Also, MPE may be has the potential to be used as a tissue-specific aromatase inhibitor (selective aromatase inhibitor) and it may be promising to develop a new therapeutic agent against ER+ breast cancer. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | The differential effects of OLE, SOE and MPE on aromatase expression showed that OLE seems to be the most potent suppressor followed by SOE and then MPE. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:69913-1 | |
| Safety | NA |