| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-715 | |
| Phytochemical name or plant extracts | Mangifera indica Extracts | |
| PMID | 34136566 | |
| Literature evidence | The results of this study provide novel findings for possible mechanism of action of M. indica (bark and seed) extracts against TNBC via PKM2 inhibition suggesting that M. indica might be of therapeutic interest for the treatment of TNBC. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract | |
| Source of phytochemicals or plant Extracts | Mangifera indica | |
| Geographical availability | Assam, Belize, China South-Central, East Himalaya, Myanmar, Thailand | |
| Plant parts | Leaves, Seeds, Bark | |
| Other cancers | Breast cancer | |
| Target gene or protein | PKM2 | |
| Gene or Protein evidence | Out of 51 plant extracts screened, four extracts Mangifera indica (leaf, seed, and bark) and Bombex ceiba bark extracts were found to be inhibitors of PKM2. | |
| Target pathways | NA | |
| IC50 | Bark extract - 108 μg/ml against MDA-MB-231 Leaves extract - 67 μg/ml against MDA-MB-231 Seed extract - 33 μg/ml against MDA-MB-231 | |
| Potency | These extracts showed different degrees of concentration-dependent inhibition against PKM2 at 90-360 μg/ml concentrations. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | The results of this study provide novel findings for possible mechanism of action of M. indica (bark and seed) extracts against TNBC via PKM2 inhibition suggesting that M. indica might be of therapeutic interest for the treatment of TNBC. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:69913-1 | |
| Safety | NA |