| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-362 | |
| Phytochemical name or plant extracts | Mammea C/BB | |
| PMID | 21214226 | |
| Literature evidence | In an effort to identify natural product-based molecular-targeted antitumor agents, mammea-type coumarins from the tropical/subtropical plant Mammea americana were found to inhibit the activation of HIF-1 (hypoxia-inducible factor-1) in human breast and prostate tumor cells. | |
| IUPAC name | 5,7-dihydroxy-8-(2-methylbutanoyl)-6-(3-methylbut-2-enyl)-4-pentylchromen-2-one | |
| Phytochemicals’ class or type of plant extracts | Coumarin | |
| Source of phytochemicals or plant Extracts | Mammea americana | |
| Geographical availability | Bahamas, Cayman Is., Cuba, Dominican Republic, Florida, Guatemala, Haiti, Jamaica, Leeward Is., Mexico Gulf, Mexico Southeast, Mexico Southwest, Puerto Rico, Southwest Caribbean, Venezuelan Antilles, Windward Is. | |
| Plant parts | Stem bark | |
| Other cancers | Breast cancer, Prostate cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 3.73 μM against T47D (1% O2, 16 h) 3.40 μM against T47D (10 μM 1,10-phen, 16 h) | |
| Potency | EC50=1.56 μM against T47D | |
| Cell line/ mice model | T47D, PC-3 | |
| Additional information | NA | |
| PubChem ID | 71438015 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:428743-1 | |
| Safety | NA |