| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2024 | |
| Phytochemical name or plant extracts | Mammea A/AA | |
| PMID | 15787438 | |
| Literature evidence | Author information: (1)Departamento de QuÃmica Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, Campus Unamuno, E-37007, Salamanca, Spain. lopez@usal.es Bioassay-guided fractionation of the CH(2)Cl(2) extract of the leaves of Marila pluricostata led to the isolation of 17 naturally occurring 4-phenylcoumarins, three of them, 5-hydroxy-8,8-dimethyl-4-phenyl-9,10-dihydro-8H-pyrano-[2,3-f]chromen-2-one (1), 5-hydroxy-8,8-dimethyl-4-phenyl-6-propionyl-9,10-dihydro-8H-pyrano-[2,3-f]chromen-2-one (2), and 5,7-dihydroxy-8-(3-methylbut-2-enyl)-4-phenylchromen-2-one (3), are new natural compounds; the remaining (4-17) are known mammea-type coumarins. | |
| IUPAC name | 5,7-dihydroxy-6-(3-methylbutanoyl)-8-(3-methylbut-2-enyl)-4-phenylchromen-2-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Marila pluricostata | |
| Geographical availability | Colombia, Costa Rica, Ecuador, Nicaragua, Panamá | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer, Lung cancer, Glioma | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | GI50 = 0.2 μg/mL for MCF-7 | |
| Cell line/ mice model | MCF-7, H-460, SF-268 | |
| Additional information | Cytotoxic potency of the crude CH2 Cl2 extract was mainly due to the 4-phenylcoumarins, of which, mammesin (4), mammea A/AB (10), mesuol (11), and mammea A/AB (12) were the most cytotoxic. | |
| PubChem ID | 5281419 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:153156-2 | |
| Safety | NA |