| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1708 | |
| Phytochemical name or plant extracts | Machilin D | |
| PMID | 32033472 | |
| Literature evidence | These results suggest that machilin D blocks IL-6 and IL-8 signaling and induces CSC death and thus may be a potential agent targeting BCSCs. | |
| IUPAC name | 4-[(1S)-1-hydroxy-2-[2-methoxy-4-[(E)-prop-1-enyl]phenoxy]propyl]-2-methoxyphenol | |
| Phytochemicals’ class or type of plant extracts | lignin | |
| Source of phytochemicals or plant Extracts | Saururus chinensis | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Hainan, Japan, Korea, Nansei-shoto, Philippines, Qinghai, Taiwan, Vietnam | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | IL-6, IL-8, NF-κB | |
| Gene or Protein evidence | These results suggest that machilin D blocks NF-κB and IL-6 and IL-8 signaling and induces CSC death. IL-6 and IL-8 regulation is important for breast CSC formation. | |
| Target pathways | Machilin D inhibited mammosphere formation through the NF-κB signaling pathway | |
| IC50 | NA | |
| Potency | These results suggest that machilin D blocks IL-6 and IL-8 signaling and induces CSC death and thus may be a potential agent targeting BCSCs. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | Machilin D inhibited the growth and mammosphere formation of breast cancer cells and inhibited tumor growth in a xenograft mouse model. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:684080-1 | |
| Safety | NA |