| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-643 | |
| Phytochemical name or plant extracts | Lunasin | |
| PMID | 20457246 | |
| Literature evidence | These compounds arrest the cell cycle in the S- and G1-phases, respectively, acting synergistically to induce apoptosis. | |
| IUPAC name | (2R)-4,8-dimethoxy-9-methyl-2-propan-2-yl-2,3-dihydrofuro[2,3-b]quinolin-9-ium | |
| Phytochemicals’ class or type of plant extracts | Novel seed peptide | |
| Source of phytochemicals or plant Extracts | Glycine max | |
| Geographical availability | Amur, China North-Central, China South-Central, China Southeast, Hainan, Inner Mongolia, Japan, Khabarovsk, Korea, Laos, Manchuria, Nansei-shoto, Primorye, Qinghai, Taiwan, Thailand, Tibet, Vietnam, Xinjiang | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | MMP2, MMP9, NOS, IL-1, IL-6, TNF-α, Src, Akt, ERK, NF-κB, MCP-1 | |
| Gene or Protein evidence | Meanwhile, we also found that lunasin inhibited the phosphorylation of focal adhesion kinase (FAK), Src, Akt, ERK and nucleus translocation of NF-κB, which indicates that, possibly via competing with αVβ3 or αVβ5/α5β1 integrin, lunasin suppresses the metastasis of breast cancer cells through integrin-mediated FAK/Akt/ERK and NF-κB signaling pathways followed by downregulation of the activity and expression of MMP-2/-9. The 6 h-LSGS presented anti-inflammatory activity on LPS-induced macrophage cells (p < 0.05) by suppressing the release of nitric oxide (NO) and proinflammatory cytokines, including IL-1 and IL-6. The gene expression of NOS, IL-1, IL-6, and TNF-α was significantly inhibited by 6 h-LSGS. Lunasin significantly inhibited interleukin (IL)-6 and macrophage chemoattractant protein (MCP)-1 secretion by TNF-α stimulation, and MCP-1 secretion in the RAW-CM model. This study highlights that lunasin suppressed 3T3-L1 adipocyte inflammation and inhibited 4T1 breast cancer cell migration. | |
| Target pathways | FAK/Akt/ERK pathway NF-κB signaling pathway | |
| IC50 | NA | |
| Potency | Lunasin/aspirin therapy exerts its potent pro-apoptotic effect is at least partially achieved through modulating the extrinsic-apoptosis dependent pathway. Synergistic down-regulatory effects were observed for ERBB2, AKT1, PIK3R1, FOS and JUN signaling genes, whose amplification has been reported as being responsible for breast cancer cell growth and resistance to apoptosis. | |
| Cell line/ mice model | MDA-MB-231, 4T1 | |
| Additional information | Lunasin/aspirin therapy exerts its potent pro-apoptotic effect is at least partially achieved through modulating the extrinsic-apoptosis dependent pathway. ALS Reversals - Lunasin Regimen | |
| PubChem ID | 20054959 | |
| Additional PMIDs | 31979146 31784283 27175819 20457246 27983683 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:60450240-2 . NCT02709330 | |
| Safety | NA |