| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1762 | |
| Phytochemical name or plant extracts | Longirostrerones A | |
| PMID | 22004007 | |
| Literature evidence | Compounds 1-4 exhibited strong cytotoxicity against KB cancer cell lines (IC(50) 0.23-6.38 μM), while only 1 showed potent cytotoxicity against MCF7 and NCI-H187 cell lines (IC50 0.24 and 3.08 μM, respectively). | |
| IUPAC name | (6aR,9S,9aR)-3-[(1S,2S,4R)-4-hydroxy-2-methyl-6-oxocyclohexyl]-6a-methyl-9-[(2E,4E)-4,6,8-trimethyldeca-2,4-dienoyl]-9,9a-dihydrofuro[2,3-h]isochromene-6,8-dione | |
| Phytochemicals’ class or type of plant extracts | Azaphilones | |
| Source of phytochemicals or plant Extracts | Chaetomium longirostre | |
| Geographical availability | NA | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 0.24 μM against MCF-7 | |
| Potency | NA | |
| Cell line/ mice model | MCF-7 | |
| Additional information | It has a role as an antineoplastic agent, an antimalarial and a Chaetomium metabolite. It is an azaphilone, a gamma-lactone and an organic heterotricyclic compound. | |
| PubChem ID | 56833382 | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |