| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-677 | |
| Phytochemical name or plant extracts | Livistona chinensis extract | |
| PMID | 16919867 | |
| Literature evidence | In conclusion, the active components with both antitumor and protein kinases inhibitor activities were highly purified from LC, which can inhibit the EGF signaling events mainly through EGFR modification. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Livistona chinensis | |
| Geographical availability | China Southeast, Hainan, Japan, Nansei-shoto, Taiwan | |
| Plant parts | Seeds | |
| Other cancers | Breast cancer, Nasopharyngeal cancer | |
| Target gene or protein | PAK2, PKA, PKC, GSK-3alpha, CK2, MAPK, JNK1, EGF | |
| Gene or Protein evidence | LC-X inhibited the activities of various protein kinases in vitro, including PAK2, PKA, PKC, GSK-3alpha, CK2, mitogen-activated protein kinase (MAPK), and JNK1, with IC(50) between approximately 1 and 40microg/ml. In conclusion, the active components with both antitumor and protein kinases inhibitor activities were highly purified from LC, which can inhibit the EGF signaling events mainly through EGFR modification. | |
| Target pathways | EGF/EGFR-mediated MAPK signaling pathway | |
| IC50 | NA | |
| Potency | In conclusion, the active components with both antitumor and protein kinases inhibitor activities were highly purified from LC, which can inhibit the EGF signaling events mainly through EGFR modification. Blockage of the functions of EGFR may account for the antitumor activity of these active components. | |
| Cell line/ mice model | HeLa, A431, MCF-7, NPC-TW02 and -TW04 | |
| Additional information | The proliferation of two NPC (NPC-TW02 and -TW04) and one breast cancer (MCF-7) cell lines, but not the epidermoid (A431) and cervical (HeLa) carcinoma cell lines, were significantly blocked by LC-X at the dose of >50microg/ml. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:668021-1 | |
| Safety | NA |