| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2186 | |
| Phytochemical name or plant extracts | Lithocarpus polystachyus extract | |
| PMID | 24660968 | |
| Literature evidence | The possible mechanism of its activity was analyzed with cell biological and molecular biological assays. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Aqueous extract | |
| Source of phytochemicals or plant Extracts | Lithocarpus polystachyus | |
| Geographical availability | Assam, Bangladesh, Cambodia, East Himalaya, Laos, Myanmar, Thailand, Vietnam | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | PPARγ, Bax, Capase 3, Cyclin D1, Bcl-2 | |
| Gene or Protein evidence | The findings in this experimental study suggested that LPAE has potential cytotoxic and apoptotic effects on human breast cancer cells in vitro and inhibits the cancer growth in vivo, and its mechanism of activity might be associated with apoptosis induction of cancer cells through upregulation of the mRNA and protein expressions of PPARγ, Bax, and capase-3 genes and downregulation of the expressions of cyclin D1 and Bcl-2 genes. | |
| Target pathways | Mitochondria pathway | |
| IC50 | 278.78 μg/mL | |
| Potency | NA | |
| Cell line/ mice model | MCF-7 | |
| Additional information | The LPAE might serve as a novel therapeutic agent in the treatment and/or prevention of human breast cancer and deserve to be investigated further. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:358942-1 | |
| Safety | NA |