| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-551 | |
| Phytochemical name or plant extracts | Liriope platyphylla extract | |
| PMID | 23762164 | |
| Literature evidence | The overall result highlights the anticancer property of LPRP-9, suggests its mechanism for inhibition of proliferation and promotion of cell death for cancer cells via regulation of multitarget pathways, and denotes the importance of purifying components of fraction LPRP-9 to aid cancer therapy. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract | |
| Source of phytochemicals or plant Extracts | Liriope platyphylla | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Japan, Korea, Nansei-shoto, Taiwan | |
| Plant parts | Root | |
| Other cancers | Breast cancer, Liver cancer, Lung cancer | |
| Target gene or protein | AKT, Bcl-2, Bcl-xL, Survivin | |
| Gene or Protein evidence | Treatment with LPRP-9 significantly inhibited proliferation of cancer cell lines MCF-7 and Huh-7 and down-regulated the phosphorylation of AKT. LPRP-9 also activates the stress-activated MPAK, JNK, p38 pathways, the p53 cell-cycle checkpoint pathway, and a series of caspase cascades while downregulating expression of antiapoptotic factors Bcl-2, Bcl-XL, and survivin. | |
| Target pathways | MPAK, JNK, p38 pathway p53 cell-cycle checkpoint pathway | |
| IC50 | 67.6 ± 0.8 μg/mL against MCF-7 57.6 ± 1.8 μg/mL against MDA-MB-231 | |
| Potency | he overall result highlights the anticancer property of LPRP-9, suggests its mechanism for inhibition of proliferation and promotion of cell death for cancer cells via regulation of multitarget pathways, and denotes the importance of purifying components of fraction LPRP-9 to aid cancer therapy. | |
| Cell line/ mice model | MCF-7, MDA-MB-231, Huh-7, Hep 3B, A549 | |
| Additional information | Here, we illustrate the anticancer activity of LPRP-9, one of the active fractions we fractionated from the Liriope platyphylla root part (LPRP) extract. | |
| PubChem ID | NA | |
| Additional PMIDs | 23578647 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:537869-1 | |
| Safety | NA |