| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-26 | |
| Phytochemical name or plant extracts | Lippia citriodora essential oil | |
| PMID | 34070804 | |
| Literature evidence | LCO was found to inhibit the growth of DA3 cells in vitro, attenuate their migration, and induce apoptosis. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Essential oil | |
| Source of phytochemicals or plant Extracts | Lippia citriodora | |
| Geographical availability | Argentina Northwest, Bolivia, Paraguay | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 3, Survivin | |
| Gene or Protein evidence | LCO Increases Cleaved Caspase 3 Levels and Reduces Protein Expression of Survivin (BIRC5a) in DA3 Tumors | |
| Target pathways | NA | |
| IC50 | At 24h, 48h, 72h 96.4 ± 8.9 μg/mL against DA3 breast cancer cells 77.8 ± 1.5 μg/m against DA3 breast cancer cells 70.7 ± 5.5 μg/mL against DA3 breast cancer cells | |
| Potency | The higher IC50 values for 24 h compared to 48 and 72 h and for 48 h compared to 72 h implied that the growth inhibitory effect exerted by LCO against DA3 cells was time dependent. | |
| Cell line/ mice model | DA3 breast cancer model in mice | |
| Additional information | Cells treated for 48 h exhibited an increase of 30% or 517%, while cells treated for 72 h exhibited an increase of 10% or a decrease of 1% (as progressively, an increasing number of cells undergoes cell death) in the ratio of early apoptotic to viable cells for 0.089 or 0.184 mg/mL of LCO, respectively. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:1015994-1 | |
| Safety | NA |