| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-239 | |
| Phytochemical name or plant extracts | Linalool | |
| PMID | 18695915 | |
| Literature evidence | A significant synergism can be observed in MCF7 AdrR cells, which may be due, at least in part, to the ability of LIN to increase DOX accumulation and to induce a decrease in Bcl-xL levels. | |
| IUPAC name | 3,7-dimethylocta-1,6-dien-3-ol | |
| Phytochemicals’ class or type of plant extracts | Monoterpene alcohol | |
| Source of phytochemicals or plant Extracts | Erythrina corallodendron | |
| Geographical availability | Dominican Republic, Haiti, Jamaica, Leeward Is., Puerto Rico, Windward Is | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 224 μM | |
| Potency | By using WST-1 analysis, it was shown that linalool and p-coumaric acid have good inhibitory effects against breast, colorectal and liver cancer cells. The IC50 values of linalool for those cancer cell types were 224 μM, 222 μM, and 290 μM, respectively | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Researchers have reported that linalool could be used as a treatment for oral cancers by acting through the PI3K/Akt pathway. | |
| PubChem ID | 6549 | |
| Additional PMIDs | 18695915 30944712 24858101 28980914 25148954 31490383 32852722 19921589 19428344 30984579 33138099 32328274 25532299 30452187 24031588 15099856 24079199 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:316421-2 | |
| Safety | NA |