| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-496 | |
| Phytochemical name or plant extracts | Licochalcone B (LCB) | |
| PMID | 27719653 | |
| Literature evidence | Emerging evidence shows that LCB may be a promising alternative compound with anti-cancer activities. | |
| IUPAC name | (E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one | |
| Phytochemicals’ class or type of plant extracts | Chalcone | |
| Source of phytochemicals or plant Extracts | Glycyrrhiza glabra | |
| Geographical availability | Afghanistan, Albania, Bulgaria, Central European Rus, China North-Central, Cyprus, East Aegean Is., East European Russia, Greece, Iran, Iraq, Italy, Kazakhstan, Kirgizstan, Krym, Lebanon-Syria, Mongolia, North Caucasus, Pakistan, Palestine, Romania, Sardegna, Saudi Arabia, Sicilia, South European Russi, Tadzhikistan, Transcaucasus, Turkey, Turkmenistan, Ukraine, Uzbekistan, West Siberia, Xinjiang, Yugoslavia | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Cyclin A, CDK2, Cdc25 A, p21, Caspase 3, Caspase 9, Bax, Bcl-2, p53 | |
| Gene or Protein evidence | Moreover, LCB-treatment led to S phase arrest in MCF-7 cells, which could be elucidated by the decreased mRNA and protein levels of Cyclin A, Cdk2 and Cdc25 A, and the increased protein level of p21. The above apoptotic events were supported by the fact that LCB upregulated the mRNA and protein levels of Caspase 3, Caspase 9 and Bax, and downregulated the mRNA and protein level of Bcl-2, which was triggered by the increased p53 protein level in LCB-treated MCF-7 cells. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | These findings suggested that LCB could be a promising agent for treatment of human breast cancer. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | LCB also induced such apoptosis morphology as phosphatidylserine externalization, chromatin condensation and DNA fragmentation. Moreover, LCB led to the loss of MMP, resulting in the release of cytochrome C. | |
| PubChem ID | 5318999 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:496941-1 | |
| Safety | NA |