| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-495 | |
| Phytochemical name or plant extracts | Licochalcone A (LCA) | |
| PMID | 28498645 | |
| Literature evidence | We investigated the anti-proliferative and apoptotic effect of LCA in human breast cancer cells MCF-7 and MDA-MB-231 through MTS assay, PI staining, Annexin-V/7-AAD assay, mitochondrial membrane potential assay, multi-caspase assay, RT-PCR, Western blot analysis, and anchorage-independent cell transformation assay. | |
| IUPAC name | (E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one | |
| Phytochemicals’ class or type of plant extracts | Chalcone | |
| Source of phytochemicals or plant Extracts | Glycyrrhiza inflata | |
| Geographical availability | China North-Central, Inner Mongolia, Mongolia, Xinjiang | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | p53, Sp1, PRMT6 | |
| Gene or Protein evidence | Licochalcone A exhibited cytotoxicity towards human MCF-7 breast cancer cells, but not MCF-10A human breast epithelial cells, by upregulating p53 expression and blocking cell cycle progression at G2/M, followed by apoptosis. Additionally, LCA showed the anti-proliferative and apoptotic effect in breast cancer cells through regulating Sp1 and apoptosis-related proteins in a dose- and a time-dependent manner. We demonstrated that licochalcone A is a non-S-adenosyl L-methionine (SAM) binding site competitive inhibitor of PRMT6. | |
| Target pathways | PI3K/Akt/mTOR pathway | |
| IC50 | NA | |
| Potency | Thus, licochalcone A has potential for further development as a therapeutic agent against breast cancer. Consequently, LCA might be a potential anti-breast cancer drug substitute. | |
| Cell line/ mice model | MDA-MB-231, MCF-7, MCF-10A | |
| Additional information | Licochalcone A is a Natural Selective Inhibitor of Arginine Methyltransferase 6. | |
| PubChem ID | 5318998 | |
| Additional PMIDs | 33245113 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:496952-1 | |
| Safety | NA |