| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1920 | |
| Phytochemical name or plant extracts | Lentinan (LNT) | |
| PMID | 29156828 | |
| Literature evidence | Interestingly, the cell viability assay, siRNA transfection, Western blotting and flow cytometric analysis suggested that LNT targeted p53/ERα to only suppress cell proliferation via cell cycle arrest at G2/M phase without apoptosis in vitro. | |
| IUPAC name | (2R,3R,4S,5S,6R)-2-[[(2R,3R,4S,5R,6R)-4-[(2S,3R,4S,5R,6R)-4-[(2S,3R,4S,5R,6R)-4-[(2S,3R,4S,5R,6R)-3,5-dihydroxy-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5,6-trihydroxyoxan-2-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol | |
| Phytochemicals’ class or type of plant extracts | Polysaccharide | |
| Source of phytochemicals or plant Extracts | Lentinus edodes | |
| Geographical availability | NA | |
| Plant parts | Mushroom | |
| Other cancers | Breast cancer | |
| Target gene or protein | p53, p-ERK1/2, cleaved-Caspase 3, PARP 1, MDM2, TERT, NF-κB (NF-κB) p65, Bcl-2, ERα, PI3K, p-AKT, mTOR | |
| Gene or Protein evidence | The Western blotting analysis indicated that LNT up-regulated the tumor suppressor p53, phosphorylated extracellular signal-regulated kinase1/2 (p-ERK1/2), cleaved-Caspase 3 and poly [ADP (ribose)] polymerase 1 (PARP 1) protein levels, and reduced the expression of mouse double minute 2 (MDM2), telomerase reverse transcriptase (TERT), nuclear factor-kappa B (NF-κB) p65, B-cell lymphoma-2 (Bcl-2), estrogen receptor α (ERα), etc. in tumor tissues. Moreover, LNT significantly suppressed phosphatidylinositol 3-kinase (PI3K), phosphorylated protein kinase B (p-Akt) and mammalian target of rapamycin (mTOR) protein levels. | |
| Target pathways | PI3K/Akt/mTOR, NF-κB-, ERK-, ERα-, caspase- and p53-dependent pathways | |
| IC50 | NA | |
| Potency | Interestingly, the cell viability assay, siRNA transfection, Western blotting and flow cytometric analysis suggested that LNT targeted p53/ERα to only suppress cell proliferation via cell cycle arrest at G2/M phase without apoptosis in vitro. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | NA | |
| PubChem ID | 37723 | |
| Additional PMIDs | 6349538 9260604 | |
| Additional sources of information | NA | |
| Safety | NA |