| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-385 | |
| Phytochemical name or plant extracts | Lavandula angustifolia extract and essential oil | |
| PMID | 24571090 | |
| Literature evidence | The herb has been used in alternative medicine for several centuries. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanol and n-hexane extract | |
| Source of phytochemicals or plant Extracts | Lavandula angustifolia | |
| Geographical availability | France, Italy, Spain | |
| Plant parts | Aerial parts | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, PARP | |
| Gene or Protein evidence | Western blot analysis demonstrated that EtOH and n-hexane extracts upregulated Bax expression, also it induced cleavage of PARP in HeLa cells compared to the control. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | In conclusion, L. angustifolia has cytotoxic and apoptotic effects in HeLa and MCF-7 cell lines, and apoptosis is proposed as the possible mechanism of action. | |
| Cell line/ mice model | HeLa, MCF-7 | |
| Additional information | Ethanol and n-hexane extracts and essential oil exhibited significant cytotoxicity to malignant cells but marginal cytotoxicity to human fibroblasts in vitro and induced a sub-G1 peak in flow cytometry histogram of treated cells compared to the control. | |
| PubChem ID | NA | |
| Additional PMIDs | 29552454 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:449008-1 | |
| Safety | NA |