| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1555 | |
| Phytochemical name or plant extracts | Laurenditerpenol | |
| PMID | 15620241 | |
| Literature evidence | Laurenditerpenol, a new diterpene from the tropical marine alga Laurenciaintricata that potently inhibits HIF-1 mediated hypoxic signaling in breast tumor cells | |
| IUPAC name | (1S)-3-methyl-6-[4-[(1R,2R,3R,4S)-1,3,4-trimethyl-7-oxabicyclo[2.2.1]heptan-2-yl]butan-2-yl]cyclohex-2-en-1-ol | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Laurenciaintricata | |
| Geographical availability | NA | |
| Plant parts | Algae | |
| Other cancers | Breast cancer | |
| Target gene or protein | HIF-1, VEGF | |
| Gene or Protein evidence | Compound 1 potently inhibited hypoxia-activated HIF-1 (IC50: 0.4 microM) and hypoxia-induced VEGF (a potent angiogenic factor) in T47D cells. | |
| Target pathways | NA | |
| IC50 | Compound 1 potently inhibited hypoxia-activated HIF-1 (IC50 - 0.4 µM). Compound 1 inhibits the mitochondrial electron transport pathway (IC50 - 0.8 µM). | |
| Potency | Compound 1 inhibits HIF-1 by blocking the induction of the oxygen-regulated HIF-1alpha protein. Mitochondrial respiration studies revealed that 1 suppresses oxygen consumption. | |
| Cell line/ mice model | T47D | |
| Additional information | Compound 1 selectively inhibits HIF-1 activation by hypoxia but not iron chelator-induced activation. Further, 1 suppresses tumor cell survival under hypoxic conditions without affecting normoxic cell growth. | |
| PubChem ID | NA | |
| Additional PMIDs | 15620241 | |
| Additional sources of information | NA | |
| Safety | NA |