| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-259 | |
| Phytochemical name or plant extracts | Lantana camara extract | |
| PMID | 25145450 | |
| Literature evidence | In this study, we identified a natural anticancer agent from Lantana camara, a flowering plant species of the genus Verbena. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Lantana camara | |
| Geographical availability | Aruba, Bahamas, Belize, Brazil North, Brazil West-Central, Cayman Is., Colombia, Costa Rica, Cuba, Dominican Republic, Ecuador, El Salvador, Guatemala, Guyana, Haiti, Honduras, Jamaica, Leeward Is., Mexico Central, Mexico Gulf, Mexico Northeast, Mexico Northwest, Mexico Southeast, Mexico Southwest, Netherlands Antilles, Nicaragua, Panamá, Puerto Rico, Southwest Caribbean, Trinidad-Tobago, Venezuela, Venezuelan Antilles, Windward Is. | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bid, Bax, Bcl-2, Caspase 8, Caspase 9, PARP | |
| Gene or Protein evidence | Bid and Bax was increased and Bcl-2 was decreased by L. camara extract. L. camara extract modulated cleavage of caspase-8, and caspase-9, as well as poly (ADP-ribose) polymerase (PARP). | |
| Target pathways | Bcl-2 pathway | |
| IC50 | 46.62 μg/mL for 6h against MCF-7 | |
| Potency | In summary, the extract obtained from L. camara showed anti-cancer effects through the induction of apoptosis in MCF7. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | 25145450 32662347 30426385 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:325686-2 | |
| Safety | NA |