| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-810 | |
| Phytochemical name or plant extracts | Lanostane | |
| PMID | 32862572 | |
| Literature evidence | PURPOSE: This study was performed to investigate the effects of lanostane against human breast cancer cells with emphasis on its potential to inhibit cancer cell growth and metastasis along with understanding the underlying molecular mechanism mediating the effects. | |
| IUPAC name | (5S,8R,9S,10R,13R,14S,17R)-4,4,10,13,14-pentamethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,5,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid | |
| Source of phytochemicals or plant Extracts | Lyonia ovalifolia | |
| Geographical availability | China North-Central, China South-Central, China Southeast | |
| Plant parts | Flowers | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, Bcl-2 | |
| Gene or Protein evidence | The antiproliferative effects of lanostane were modulated through Bax/Bcl-2 pathway inducing apoptosis of cancer cells. | |
| Target pathways | Rho-associated kinases (ROCK) signaling pathway | |
| IC50 | NA | |
| Potency | The results of the present study are suggestive of anticancer effects of lanostene triterpene which exerted its effects by inhibiting cell proliferation and metastasis of breast cancer cells mediated through inactivation of Rho-associated kinase signaling. The study holds promise to provide a lead for exploring the secondary metabolite-based anticancer approach against various human malignancies. | |
| Cell line/ mice model | SKBR-3, MB-157 | |
| Additional information | The inhibition of cell metastasis was modulated through Rho-associated kinases (ROCK) signaling pathway which is involved in metastasis of breast cancer to bone tissues. Hence, the results suggested that lanostane inhibited the breast cancer metastasis to bone. | |
| PubChem ID | 9548665 | |
| Additional PMIDs | 33830612 25457485 32007721 32862572 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:77250333-1 | |
| Safety | NA |