| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-295 | |
| Phytochemical name or plant extracts | Kopetdaghinane A | |
| PMID | 32464255 | |
| Literature evidence | Cytotoxic activity of kopetdaghinane A was evaluated using standard MTT assay against MCF-7 breast cancer and OVCAR-3 ovary cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Euphorbia kopetdaghi | |
| Geographical availability | Iran, Turkmenistan | |
| Plant parts | Aerial parts | |
| Other cancers | Breast cancer, Ovarian cancer | |
| Target gene or protein | Bcl-2, Bax | |
| Gene or Protein evidence | Western blot analysis showed that the expression of Bcl-2 was noticeably decreased in response to kopetdaghinane A treatment, while the expression of Bax protein was increased. | |
| Target pathways | Mitochondrial apoptotic pathway | |
| IC50 | NA | |
| Potency | Kopetdaghinane A inhibits the growth of MCF-7 breast cancer cells through the activation of the mitochondrial apoptotic pathway and may be considered as an investigational compound in breast cancer preclinical study. | |
| Cell line/ mice model | MCF-7, OVCAR-3 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:347014-1 | |
| Safety | NA |