| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-268 | |
| Phytochemical name or plant extracts | Kongensin D (6) | |
| PMID | 34236840 | |
| Literature evidence | All these results suggested that 6 may serve as a promising lead for the development of novel anti-TNBC agents in the future. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Croton kongensis | |
| Geographical availability | China South-Central, Hainan, Laos, Myanmar, Thailand, Vietnam | |
| Plant parts | Stem | |
| Other cancers | Breast cancer | |
| Target gene or protein | AKT, p21, Cyclin B1, CDK1, Bcl-2, Bax, Caspase 3, PARP, β-catenin, MMP2, MMP9 | |
| Gene or Protein evidence | The mechanistic study revealed that 6 induced apoptosis, autophagy, and metastasis suppression in TNBC cells via inhibition of Akt. In 6-treated TNBC cells, the expression of p21 was significantly upregulated while the expression of cyclin B1 and CDK1 were downregulated, suggesting that 6 induced TNBC cell G2/M arrest via regulation of these cell-cycle-related proteins. 6 decreased the ratios of bcl2/bax and significantly increased c-caspase 3 and c-PARP, suggesting that 6 could induce apoptosis via regulation of these cell death-related proteins. The treatment of 6 dose-dependently reduced the expression of β-catenin, MMP2, and MMP9 in MDA-MB-231 cells, confirming the antimetastatic potential of 6 in TNBC cells. | |
| Target pathways | Extracellular-regulated kinase (ERK) signaling | |
| IC50 | 0.0783 ± 0.00610 μM against MDA-MB-231 0.0716 ± 0.00228 μM against MDA-MB-468 0.113 ± 0.0103 μM against MCF-7 | |
| Potency | In vivo, 6 significantly suppressed the TNBC tumor growth without causing side effects. All these results suggested that 6 may serve as a promising lead for the development of novel anti-TNBC agents in the future. | |
| Cell line/ mice model | MDA-MB-231, MDA-MB-468, MCF-7, TNBC xenograft mouse model | |
| Additional information | All these results suggested that 6 may serve as a promising lead for the development of novel anti-TNBC agents in the future. | |
| PubChem ID | 101434818 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:342785-1 | |
| Safety | NA |