| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2116 | |
| Phytochemical name or plant extracts | Kola acuminate extract | |
| PMID | 17275869 | |
| Literature evidence | Krystal_Fontenot_01@subr.edu Kola acuminate, also known as Bizzy Nut or Kola Nut, is a natural product that contains bioactive chemicals that possess hormonal properties. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | E1 - hexane, E2 - ether, E3 - acetone, E4 - methanol and E5 - aqueous extract | |
| Source of phytochemicals or plant Extracts | Kola acuminate | |
| Geographical availability | Angola, Benin, Cabinda, Cameroon, Central African Repu, Congo, Gabon, Gulf of Guinea Is., Nigeria, Togo, Zaïre | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Prostate cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | In MCF-7 cells, the acetone extract (E3) at 100 ppm elicited a potent cytotoxic response with a growth-inhibitory concentration (GI(50)) of 67 ppm. | |
| Cell line/ mice model | MCF-7, MDA-MB-468, LNCaP | |
| Additional information | On the other hand, the acetone extract (E3), which showed the highest degree of cytotoxicity, showed no transcription stimulation of pS2 in MCF-7 cells. Altogether, these data indicate that Bizzy contains unique active hormonal compounds that have specific biological properties that are cell line-dependent. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:822645-1 | |
| Safety | NA |