| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1850 | |
| Phytochemical name or plant extracts | Kochia scoparia extract (MEKS) | |
| PMID | 25298688 | |
| Literature evidence | CONCLUSION: These results suggest that MEKS inhibits cell proliferation and induces apoptosis in breast cancer cells and that MEKS may have potential chemotherapeutic value for the treatment of human breast cancer. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract | |
| Source of phytochemicals or plant Extracts | Kochia scoparia Scharder | |
| Geographical availability | Altay, Amur, Buryatiya, China North-Central, China South-Central, China Southeast, Cyprus, East European Russia, Hainan, Inner Mongolia, Iran, Iraq, Japan, Kazakhstan, Khabarovsk, Kirgizstan, Korea, Krasnoyarsk, Lebanon-Syria, Manchuria, Mongolia, North Caucasus, North European Russi, Northwest European R, Primorye, Qinghai, Sakhalin, South European Russi, Tadzhikistan, Tibet, Transcaucasus, Turkey, Turkmenistan, Tuva, Uzbekistan, West Siberia, Xinjiang | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 3, Caspase 8, Caspase 9,PARP | |
| Gene or Protein evidence | MEKS induced apoptosis by increasing the levels of apoptosis-associated proteins such as cleaved caspase 3, cleaved caspase 8, cleaved caspase 9 and cleaved Poly (ADP-ribose) polymerase (PARP). | |
| Target pathways | NA | |
| IC50 | 36.2 μg/ml against MDA-MB-231 | |
| Potency | These results suggest that MEKS inhibits cell proliferation and induces apoptosis in breast cancer cells and that MEKS may have potential chemotherapeutic value for the treatment of human breast cancer. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | The fruit of Kochia scoparia Scharder is widely used as a medicinal ingredient for the treatment of dysuria and skin diseases in China, Japan and Korea. Especially, K. scoparia had been used for breast masses and chest and flank pain. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:164422-1 | |
| Safety | NA |