| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1044 | |
| Phytochemical name or plant extracts | Kigelia Africana, Ximenia Caffra and Mimusops Zeyheri Seed Oils | |
| PMID | 35129016 | |
| Literature evidence | Consequently, ethnomedicines are used and their efficacy as potential alternatives are being scientifically explored. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Oil | |
| Source of phytochemicals or plant Extracts | Kigelia Africana, Ximenia Caffra and Mimusops Zeyheri | |
| Geographical availability | Kigelia Africana - Angola, Benin, Botswana, Burkina, Burundi, Cameroon, Caprivi Strip, Central African Repu, Chad, Congo, Eritrea, Ethiopia, Gabon, Gambia, Ghana, Guinea, Gulf of Guinea Is., Ivory Coast, Kenya, KwaZulu-Natal, Liberia, Malawi, Mali, Mozambique, Namibia, Niger, Nigeria, Northern Provinces, Rwanda, Senegal, Sierra Leone, Somalia, Sudan, Swaziland, Tanzania, Togo, Uganda, Zambia, Zaïre, Zimbabwe Ximenia Caffra - Angola, Botswana, Burundi, Caprivi Strip, Comoros, Ethiopia, Kenya, KwaZulu-Natal, Madagascar, Malawi, Mozambique, Namibia, Northern Provinces, Rwanda, Somalia, Sudan, Swaziland, Tanzania, Uganda, Zambia, Zimbabwe Mimusops Zeyheri - Angola, Botswana, Cape Provinces, Caprivi Strip, KwaZulu-Natal, Malawi, Mozambique, Northern Provinces, Swaziland, Tanzania, Zambia, Zaïre, Zimbabwe | |
| Plant parts | Seeds | |
| Other cancers | Breast cancer | |
| Target gene or protein | CD62P, CD63 | |
| Gene or Protein evidence | An increase in CD62P and CD63 expression following whole blood exposure to untreated breast cancer cells was observed. Treated MDA-MB-231 cells reduced CD62P and CD63 expression while treated MCF-7 cells increased CD62P and decreased CD63 expression. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Kigelia africana, Ximenia caffra and Mimusops zeyheri seed oils are able to reduce the thrombogenic ability of MDA-MB-231 breast cancer cells. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:109874-1 https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:608572-1 https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:788090-1 | |
| Safety | NA |