| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-512 | |
| Phytochemical name or plant extracts | Kievitone | |
| PMID | 7794275 | |
| Literature evidence | However, genistein was about 5-fold more potent than kievitone as an inhibitor of solubilised epidermal growth factor (EGF) receptor kinase activity and EGF receptor autophosphorylation. | |
| IUPAC name | 3-(2,4-dihydroxyphenyl)-5,7-dihydroxy-8-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Phaseolus vulgaris | |
| Geographical availability | Costa Rica, Guatemala, Honduras, Mexico Central, Mexico Gulf, Mexico Northeast, Mexico Northwest, Mexico Southeast, Mexico Southwest, Nicaragua, Panamá | |
| Plant parts | Seeds | |
| Other cancers | Breast cancer | |
| Target gene or protein | EGFR kinase | |
| Gene or Protein evidence | However, genistein was about 5-fold more potent than kievitone as an inhibitor of solubilised epidermal growth factor (EGF) receptor kinase activity and EGF receptor autophosphorylation. | |
| Target pathways | NA | |
| IC50 | 1-3 μM against MCF-7 | |
| Potency | Compared with kievitone, genistein was 3-9 fold weaker as an inhibitor of the proliferation of the breast cancer cell lines and of growth factor-stimulated DNA synthesis. | |
| Cell line/ mice model | MCF-7, T47D, SKBR-3 | |
| Additional information | This work provides evidence that the red kidney bean phytoalexins kievitone and phaseollin possess both estrogenic and antiestrogenic activities. | |
| PubChem ID | 119269 | |
| Additional PMIDs | 21133423 7794275 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:514191-1 | |
| Safety | NA |