| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1311 | |
| Phytochemical name or plant extracts | Khz (fusion of Ganoderma lucidum and Polyporus umbellatus) | |
| PMID | 26648109 | |
| Literature evidence | The anti?proliferative and pro?apoptotic effects of Khz suggest that this extract may be developed as a potential anticancer agent. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | NA | |
| Source of phytochemicals or plant Extracts | Ganoderma lucidum and Polyporus umbellatus | |
| Geographical availability | China, Japan, and other Asian countries. | |
| Plant parts | Mycelia | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 7, Caspase 8, Caspase 9 | |
| Gene or Protein evidence | Assessment of the activation status of caspases 7, 8 and 9 revealed that the levels of cleaved caspases were significantly increased in the cells treated with Khz. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Treatment with 1/2 Khz for 24 h resulted in significant inhibition of cell proliferation. | |
| Cell line/ mice model | MCF?7 | |
| Additional information | Khz inhibited cell proliferation and induced apoptosis in the MCF-7 cells. Khz induced apoptosis preferentially in transformed cells, with a minimal effect on non?transformed cells, suggesting its potential as an anticancer therapeutic agent. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |