| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-996 | |
| Phytochemical name or plant extracts | Khat (Extract of Catha edulis) | |
| PMID | 28943902 | |
| Literature evidence | The results of the present study demonstrated that treatment with 400 µg/ml khat was able to induce cell death in breast cancers, with an increase in the protein expression of apoptosis regulator Bax and a decrease in the expression of B-cell lymphoma 2, along with a decrease in ROS levels in a time-dependent manner. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Catha edulis | |
| Geographical availability | Angola, Cape Provinces, Eritrea, Ethiopia, Kenya, KwaZulu-Natal, Malawi, Mozambique, Northern Provinces, Sudan, Swaziland, Tanzania, Uganda, Zambia, Zaïre, Zimbabwe | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, Bcl-2, p-JNK, p-ERK | |
| Gene or Protein evidence | The results of the present study revealed that Bcl-2 expression was decreased and Bax was increased in a time-dependent manner in khat-treated MDA-MB-231 cells, with an increase in Bax/Bcl-2 ratio. In the present study, western blotting demonstrated that the levels of p-JNK and p-ERK were increased following treatment with khat in a time-dependent manner | |
| Target pathways | JNK signaling pathway | |
| IC50 | NA | |
| Potency | The results of the present study suggest that khat induces MDA-MB-231 cell apoptosis via MAPK activation and mitochondrial-mediated death. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | The results of the present study demonstrated that treatment with 400 µg/ml khat was able to induce cell death in breast cancers, with an increase in the protein expression of apoptosis regulator Bax and a decrease in the expression of B-cell lymphoma 2, along with a decrease in ROS levels in a time-dependent manner. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:941530-1 | |
| Safety | NA |