| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-637 | |
| Phytochemical name or plant extracts | Kelussia odoratissima Mozaff. extract | |
| PMID | 28203057 | |
| Literature evidence | It induced apoptosis, transduced the cell death signals, decreased the threshold of mitochondrial membrane potential (MMP), upregulated Bax and downregulated Bcl-2. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract | |
| Source of phytochemicals or plant Extracts | Kelussia odoratissima | |
| Geographical availability | Iran | |
| Plant parts | Whole plant | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, Bcl-2, p21, p27 | |
| Gene or Protein evidence | The upregulation of these proteins can stop the proliferation of the cells as indicated by our results, which show the upregulation of p21 and p27 after treatment with 8-hydroxy-ar-turmerone and KME in vitro and in vivo, respectively, while there was no significant expression in the cancer control group. Our data proposed that KME can initiate antiproliferative and apoptotic effects and destroy the tumor cells by disrupting the cell membrane and dysfunctioning the mitochondrial metabolic cascade, as well as disrupting the expression of Bax and Bcl-2 via the intrinsic pathway. | |
| Target pathways | NA | |
| IC50 | 11.97±1.82 μg/mL against MCF-7 | |
| Potency | This study demonstrated that K. odoratissima exhibits antitumor activity against breast cancer cells via cell death and cell cycle arrest. | |
| Cell line/ mice model | MCF-7, LA7, MCF-10A | |
| Additional information | Our results demonstrated that K. odoratissima has an obvious effect on the arrest of proliferation of cancer cells. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:60431916-2 | |
| Safety | The results of the acute toxicity study show the nontoxic nature of KME, and the microscopic observation illustrates the glomeruli without signs of toxicity or fibrosis with normal hepatic lobules and renal ducts. |