| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-654 | |
| Phytochemical name or plant extracts | Kaempferol-3-O-rhamnoside | |
| PMID | 22783393 | |
| Literature evidence | Our results provide a basis for further exploration of kaempferol-3-O-rhamnoside as an active compound for potential anti-cancer therapeutics. | |
| IUPAC name | 5,7-dihydroxy-2-(4-hydroxyphenyl)-3-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxychromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Schima wallichii | |
| Geographical availability | Assam, Bangladesh, Borneo, Cambodia, China South-Central, China Southeast, East Himalaya, Jawa, Laos, Lesser Sunda Is., Malaya, Myanmar, Nepal, Philippines, Sumatera, Thailand, Tibet, Vietnam | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 9, Caspase 3, PARP | |
| Gene or Protein evidence | Results showed that in MCF-7 cells, kaempferol-3-O-rhamnoside inhibits cell proliferation in a dose-dependent manner and promotes apoptosis via the activation of the caspase signaling cascade, which includes caspase-9, caspase-3 and PARP. | |
| Target pathways | Caspase cascade pathway Mitochondrial caspase-9 pathway | |
| IC50 | 227 μM against MCF-7 | |
| Potency | our results emphasize the potential application of kaempferol-3-O-rhamnoside in the management and treatment of cancer. | |
| Cell line/ mice model | MCF-7, HC-04 | |
| Additional information | Although kaempferol-3-O-rhamnoside affects the proliferation of non-cancer HC-04 cells, the IC50 concentration required was also significantly higher than that required for cancer MCF-7 cells, suggesting that kaempferol-3-O-rhamnoside may be less cytotoxic to non-cancer cells. | |
| PubChem ID | 5835713 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:60457200-2 | |
| Safety | NA |