| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-54 | |
| Phytochemical name or plant extracts | Kaempferide | |
| PMID | 11525602 | |
| Literature evidence | Further examination in HEK-293 cells transfected with ERalpha or ERbeta demonstrated potent antagonism with kaempferide and apigenin, while flavone was weakly antagonistic only toward ERP. | |
| IUPAC name | 3,5,7-trihydroxy-2-(4-methoxyphenyl)chromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Azadirachta indica | |
| Geographical availability | Assam, Bangladesh, Cambodia, Laos, Myanmar, Thailand, Vietnam | |
| Plant parts | Flowers | |
| Other cancers | Breast cancer, Prostate cancer, Gastric cancer, Lung cancer, Leukemia | |
| Target gene or protein | ER | |
| Gene or Protein evidence | We conclude that antiestrogenic activities of flavonoid phytochemicals may occur through ER binding-dependent and -independent mechanisms and that the binding-independent antiestrogen activity of certain flavonoids is biologically significant in regulation of breast cancer cell proliferation. | |
| Target pathways | NA | |
| IC50 | 81.2±8.0 μM against SKBR-3 | |
| Potency | NA | |
| Cell line/ mice model | HL60, A549, AZ521, SKBR-3, MCF-7,PC-3, T-47D | |
| Additional information | Several flavonoids, including kaempferide, apigenin, and flavone, were distinct, in that their antiestrogenic activity did not appear to correlate with binding to ER, and therefore their suppression of estrogen-mediated gene transactivation and proliferation may occur independent of direct antagonism of the receptor. | |
| PubChem ID | 5281666 | |
| Additional PMIDs | 26047480 31493543 11525602 23123452 26345098 24443427 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:1213180-2 | |
| Safety | NA |