| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2059 | |
| Phytochemical name or plant extracts | Juniperus communis extract (#46) | |
| PMID | 27023497 | |
| Literature evidence | Although many of these compounds have interesting individual biological activities, their natural blends seem to exert specific effects on the proliferation of cell lines either growing adherent or in suspension, suggesting potential use in fighting cancer. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract | |
| Source of phytochemicals or plant Extracts | Juniperus communis. | |
| Geographical availability | Afghanistan, Alabama, Alaska, Albania, Algeria, Altay, Amur, Arizona, Austria, Baltic States, Belarus, Belgium, British Columbia, Bulgaria, Buryatiya, California, Central European Rus, Chita, Colorado, Connecticut, Corse, Cyprus, Czechoslovakia, Denmark, East Aegean Is., East European Russia, Finland, France, Føroyar, Georgia, Germany, Great Britain, Greece, Greenland, Hungary, Iceland, Idaho, Illinois, Indiana, Inner Mongolia, Iowa, Iran, Iraq, Ireland, Irkutsk, Italy, Japan, Kamchatka, Kazakhstan, Kentucky, Khabarovsk, Kirgizstan, Korea, Krasnoyarsk, Krym, Kuril Is., Labrador, Lebanon-Syria, Magadan, Maine, Manchuria, Maryland, Massachusetts, Michigan, Minnesota, Mongolia, Montana, Morocco, Nebraska, Nepal, Netherlands, Nevada, New Brunswick, New Hampshire, New Jersey, New Mexico, New York, Newfoundland, North Carolina, North Caucasus, North Dakota, North European Russi, Northwest European R, Northwest Territorie, Norway, Nova Scotia, Nunavut, Ohio, Ontario, Oregon, Pakistan, Pennsylvania, Poland, Portugal, Primorye, Prince Edward I., Québec, Rhode I., Romania, Sakhalin, Sardegna, Sicilia, South Carolina, South Dakota, South European Russi, Spain, Sweden, Switzerland, Tadzhikistan, Tennessee, Transcaucasus, Turkey, Turkey-in-Europe, Turkmenistan, Tuva, Ukraine, Utah, Uzbekistan, Vermont, Virginia, Washington, West Himalaya, West Siberia, West Virginia, Wisconsin, Wyoming, Xinjiang, Yakutskiya, Yugoslavia, Yukon | |
| Plant parts | Whole plant | |
| Other cancers | Breast cancer, Lung cancer, Leukemia | |
| Target gene or protein | p53, CDK2, p21, Bcl-2, Caspase 9 | |
| Gene or Protein evidence | It appears that the arrest in the G2/M phase induced by extract #46 is accompanied by an increase in p53 expression in both A549 and MCF-7 cells. The expression of Cdk2 by A549 and MCF-7 cells treated with extracts #46 and #57 changes as the electrophoretic doublet, present in controls, tends to fade following a decrease in the kinase activity. p21 is strongly expressed in MCF-7 cells, while no evident changes have been observed in A549 cells. Our observations are limited to changes in Bcl-2 expression and Caspase 9 activation in the MCF-7 cells only by extract #46. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Only the extracts of J. communis and C. coggygria showed marked cytotoxic effects, affecting both cell morphology and growth. A dose-dependent effect of these two extracts was also observed on the cell cycle distribution. Incubation of all the cell lines in a medium containing J. communis extract determined a remarkable accumulation of cells in the G2/M phase, whereas the C. coggygria extract induced a significant increase in the percentage of G1 cells. | |
| Cell line/ mice model | A549, MCF-7, TK6, U937 | |
| Additional information | The novelty of our findings stands on the observation that the two extracts, consistently, elicited coherent effects on the cell cycle in four cell lines, independently from their phenotype, as two of them have epithelial origin and grow adherent and two are lymphoblastoid and grow in suspension. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:30088655-2 | |
| Safety | NA |