| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1214 | |
| Phytochemical name or plant extracts | Jujuboside B | |
| PMID | 34630073 | |
| Literature evidence | The purpose of this study was to examine whether JB could prevent breast cancer and its underlying mechanism. | |
| IUPAC name | (2S,3R,4R,5R,6S)-2-[(2S,3R,4S,5S)-4-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-[[(1S,2R,5R,7S,10R,11R,14R,15S,16S,18R,20S)-16-hydroxy-2,6,6,10,16-pentamethyl-18-(2-methylprop-1-enyl)-19,21-dioxahexacyclo[18.2.1.01,14.02,11.05,10.015,20]tricosan-7-yl]oxy]oxan-3-yl]oxy-6-methyloxane-3,4,5-triol | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid | |
| Source of phytochemicals or plant Extracts | Zizyphus jujuba | |
| Geographical availability | China North-Central, China Southeast, Inner Mongolia, Korea, Manchuria, Xinjiang | |
| Plant parts | Seeds | |
| Other cancers | Breast cancer | |
| Target gene or protein | PARP, Caspase 3, LC3-II | |
| Gene or Protein evidence | the expression of cleaved PARP, cleaved caspase-3, and LC3-II increased in JB-treated tissue. | |
| Target pathways | AMPK signaling pathway | |
| IC50 | 54.38 µM against MDA-MB-231 74.94 µM against MCF-7 | |
| Potency | Further in vivo study showed that JB significantly suppressed the growth of MDA-MB-231 and MCF-7 xenografts. | |
| Cell line/ mice model | MDA-MB-231 and MCF-7 xenografts | |
| Additional information | In conclusion, our findings indicate that JB exerts its anti-breast cancer effect in association with the induction of apoptosis and autophagy. | |
| PubChem ID | 24721031 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:719213-1 | |
| Safety | NA |