| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-378 | |
| Phytochemical name or plant extracts | Juglanin | |
| PMID | 27899257 | |
| Literature evidence | We reported here that juglanin could inhibit cell proliferation by leading to G2/M phase arrest. | |
| IUPAC name | 3-[(2S,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Juglans mandshurica | |
| Geographical availability | Amur, China North-Central, China South-Central, China Southeast, Inner Mongolia, Japan, Khabarovsk, Korea, Kuril Is., Manchuria, Primorye, Sakhalin, Taiwan | |
| Plant parts | Husks | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 3, Caspase 8, Caspase 9, LC3B-II, JNK | |
| Gene or Protein evidence | Exposure to juglanin resulted in the activation of cleaved caspase -3, -8, and -9, indicating that juglanin induced apoptosis. Autophagy occurred in juglanin-treated cells as evidenced by formation of autophagosome and up-regulation of LC3B-II. | |
| Target pathways | ROS/JNK signaling pathway | |
| IC50 | 26.35 µM for 24h against MCF-7 20.07 µM for 24h against SKBR-3 29.13 µM for 24h against MDA-MB-231 24.17 µM for 24h against BT474 14.38 µM for 48h against MCF-7 17.69 µM for 48h against SKBR-3 23.25 µM for 48h against MDA-MB-231 19.85 µM for 48h against BT474 | |
| Potency | Hence, juglanin might be a promising candidate for development of anti-tumor drugs targeting breast cancer. | |
| Cell line/ mice model | SKBR-3, MCF-7, MDA-MB-231, BT-474, mouse xenograft model | |
| Additional information | The JNK inhibitor attenuated juglanin-caused apoptosis and autophagy significantly while ROS scavenger could reverse them. In addition, the ROS scavenger also inhibited G2/M phase arrest and phosphorylated JNK. Of note, we found that juglanin had the similar effects on breast cancer cells. Finally, juglanin inhibited tumor growth in the mouse xenograft model in vivo. | |
| PubChem ID | 5318717 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:442388-1 | |
| Safety | NA |