| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-283 | |
| Phytochemical name or plant extracts | Jolkinolide B | |
| PMID | 23129237 | |
| Literature evidence | In addition, treatment with JB was able to induce downregulation of cyclinD1, cyclinE, mTOR, p-PI3K and p-Akt, and upregulation of PTEN and p-eIF4E. | |
| IUPAC name | (1S,3R,8R,10R,11R,12R,17R)-5,12,16,16-tetramethyl-2,7,9-trioxahexacyclo[9.8.0.01,3.04,8.08,10.012,17]nonadec-4-en-6-one | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Euphorbia fischeriana | |
| Geographical availability | China North-Central, Chita, Inner Mongolia, Korea, Manchuria, Mongolia | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | Cyclin D1, Cyclin E, mTOR, PI3K, AKT, PTEN, eIF4E, β1-integrin, FAK, U0126, ERK | |
| Gene or Protein evidence | In addition, treatment with JB was able to induce downregulation of cyclinD1, cyclinE, mTOR, p-PI3K and p-Akt, and upregulation of PTEN and p-eIF4E. Collectively, JB-induced apoptosis of MCF-7 cells occurs through the PI3K/Akt/mTOR signaling pathway. In the present study, the anti-adhesion and anti-invasion effects of jolkinolide B, a diterpenoid compound from Euphorbia fischeriana Steud, that were exerted through suppression of β1-integrin expression and phosphorylation of focal adhesion kinase (FAK) were examined in human breast cancer MDA-MB-231 cells. Jolkinolide B inhibited the adhesion of MDA-MB-231 cells to fibronectin but not to poly-L-lysine. In addition, jolkinolide B inhibited extracellular signal-regulated kinase (ERK) phosphorylation. U0126, an ERK inhibitor, also suppressed the invasion and adhesion of MDA-MB-231 cells. | |
| Target pathways | PI3K/Akt/mTOR signaling pathway FAK-mediated signaling pathways | |
| IC50 | NA | |
| Potency | The growth of MCF-7 cells was inhibited and arrested in the S phase by JB. The data showed significantly decreased tumor volume and weight in nude mice inoculated with MCF-7 cells. | |
| Cell line/ mice model | Female Balb/c nude mice, MCF-7, BT-474, MDA-MB-231 | |
| Additional information | Collectively, JB-induced apoptosis of MCF-7 cells occurs through the PI3K/Akt/mTOR signaling pathway. Furthermore, the PI3K/Akt signaling cascade plays a role in the induction of apoptosis in JB-treated cells. Jolkinolide B regulates the luminal A and luminal B subtypes of breast cancer through PI3K-Akt, EGFR and other pathways. Jolkinolide B has more significant therapeutic effect on luminal B subtype breast cancer. In vitro, experiments verified that Jolkinolide B significantly inhibited the proliferation and migration activity of BT-474 breast cancer cells by downregulating the PI3K-Akt pathway. | |
| PubChem ID | 161954 | |
| Additional PMIDs | 23129237 34464697 26622636 22426554 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:346510-1 | |
| Safety | NA |