| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-293 | |
| Phytochemical name or plant extracts | Jolkinol A | |
| PMID | 27000121 | |
| Literature evidence | A number of compounds (2, 6, 7, 10, 11, 13, 16, 19, 20, 22, and 23) showed inhibitory activity on the formation of mammospheres in human breast cancer MCF-7 cells at a final concentration of 10 μM, suggesting the potential of these bioactive diterpenoids for further investigation of the action targeting cancer stem cells. | |
| IUPAC name | [(10Z)-16-hydroxy-11-(hydroxymethyl)-4,8,8,15-tetramethyl-12-oxo-3-oxatetracyclo[11.3.0.02,4.07,9]hexadec-10-en-13-yl] (E)-3-phenylprop-2-enoate | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Euphorbia fischeriana | |
| Geographical availability | SE. Siberia to N. & E. China and Korea | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | A number of compounds (2, 6, 7, 10, 11, 13, 16, 19, 20, 22, and 23) showed inhibitory activity on the formation of mammospheres in human breast cancer MCF-7 cells at a final concentration of 10 μM, suggesting the potential of these bioactive diterpenoids for further investigation of the action targeting cancer stem cells. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | NA | |
| PubChem ID | 6449904 | |
| Additional PMIDs | 15114502 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:346510-1 | |
| Safety | NA |