| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2076 | |
| Phytochemical name or plant extracts | Jatrophone (JA) | |
| PMID | 29281678 | |
| Literature evidence | The natural compound Jatrophone interferes with Wnt/β-catenin signaling and inhibits proliferation and EMT in human triple-negative breast cancer. | |
| IUPAC name | (1R,3R,6Z,9Z)-3,7,11,11,14-pentamethyl-16-oxatricyclo[11.2.1.01,5]hexadeca-4,6,9,13-tetraene-8,15-dione | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Jatropha gossypiifolia | |
| Geographical availability | Argentina Northwest, Aruba, Bahamas, Bolivia, Brazil North, Brazil Northeast, Brazil South, Brazil Southeast, Brazil West-Central, Cayman Is., Colombia, Costa Rica, Cuba, Dominican Republic, Ecuador, El Salvador, French Guiana, Guatemala, Guyana, Haiti, Honduras, Jamaica, Leeward Is., Mexico Gulf, Mexico Northeast, Mexico Northwest, Mexico Southeast, Mexico Southwest, Netherlands Antilles, Nicaragua, Panamá, Paraguay, Peru, Puerto Rico, Southwest Caribbean, Suriname, Trinidad-Tobago, Turks-Caicos Is., Venezuela, Venezuelan Antilles, Windward Is. | |
| Plant parts | Root and Stem | |
| Other cancers | Breast cancer | |
| Target gene or protein | AXIN2, HMGA2, MYC, PCNA, CCND1, EMT | |
| Gene or Protein evidence | JA interfered with cell cycle progression, and induced loss of expression of the canonical Wnt-direct targets genes AXIN2, HMGA2, MYC, PCNA and CCND1. The natural compound Jatrophone interferes with Wnt/β-catenin signaling and inhibits proliferation and EMT in human triple-negative breast cancer | |
| Target pathways | Wnt/β-catenin signaling pathway | |
| IC50 | ~2.0 μM against MDA-MB-231 ~1.0 μM againstMDA-MB-468 | |
| Potency | JA also caused the loss of expression of key EMT markers and significantly impaired wound healing in scratch assays, suggesting a direct role for JA inhibiting migration of TNBC cells. These results indicate that Jatrophone could be a powerful new chemotherapeutic agent against highly chemoresistant triple negative breast cancers by targeting the oncogenic Wnt10b/β-catenin signaling pathway. | |
| Cell line/ mice model | MDA-MB-231, MDA-MB-157, HCC-38, MDA-MB-468 | |
| Additional information | Elevated WNT10B expression also coincided with increased resistance to JA exposure in several metastatic cell lines. | |
| PubChem ID | 5281373 | |
| Additional PMIDs | 29771986 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:323930-2 | |
| Safety | NA |