| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-62 | |
| Phytochemical name or plant extracts | Jatropha curcas extract | |
| PMID | 25199565 | |
| Literature evidence | CONCLUSION: PS, JCP1 and JCP2 were found to be very active against MCF-7 cells by inducing anoikis and therefore possessing vast potential as medicinal drugs especially in estrogen receptor positive breast cancer treatment. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Jatropha curcas | |
| Geographical availability | Argentina Northeast, Argentina Northwest, Belize, Bolivia, Brazil North, Brazil Northeast, Brazil South, Brazil Southeast, Brazil West-Central, Chile North, Colombia, Costa Rica, Cuba, Dominican Republic, Ecuador, El Salvador, Guatemala, Guyana, Haiti, Honduras, Jamaica, Leeward Is., Mexico Central, Mexico Gulf, Mexico Northeast, Mexico Southeast, Mexico Southwest, Nicaragua, Panamá, Paraguay, Peru, Puerto Rico, Trinidad-Tobago, Uruguay, Venezuela, Windward Is. | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | β1-integrin, FAK | |
| Gene or Protein evidence | In parallel cell detachment was accompanied by decreased β1- integrin expression and phosphorylation of the focal adhesion kinase at Tyr397. | |
| Target pathways | NA | |
| IC50 | 36.55 μg/ml against MCF-7 | |
| Potency | PS, JCP1 and JCP2 were found to be very active against MCF-7 cells by inducing anoikis and therefore possessing vast potential as medicinal drugs especially in estrogen receptor positive breast cancer treatment. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Jatropha curcas (JCP1), Pyrenacantha staudtii (PS) and Jatropha gossypifolia (JCP2) were found to be very active against MCF-7 cells by inducing anoikis. | |
| PubChem ID | NA | |
| Additional PMIDs | 25199565 23811432 22814822 26209936 22016638 34669111 23773434 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:131462-2 | |
| Safety | NA |