| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1205 | |
| Phytochemical name or plant extracts | Jatamanvaltrate P | |
| PMID | 28292011 | |
| Literature evidence | These results suggest that Jatamanvaltrate P is a potential therapeutic agent for breast cancer, providing a basis for development of the compound as a novel chemotherapeutic agent. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Iridoid ester | |
| Source of phytochemicals or plant Extracts | Valeriana jatamansi Jones | |
| Geographical availability | Afghanistan, Assam, China North-Central, China Southeast, East Himalaya, Myanmar, Nepal, Pakistan, Thailand, Tibet, Vietnam, West Himalaya | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | PARP, Cyclin B1, Cyclin D1, Cdc-2 | |
| Gene or Protein evidence | Further study of the molecular mechanisms of this cytotoxic compound demonstrated that Jatamanvaltrate P enhanced cleavage of PARP and caspases, while decreased the expression levels of cell cycle-related Cyclin B1, Cyclin D1 and Cdc-2. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | These results suggest that Jatamanvaltrate P is a potential therapeutic agent for breast cancer, providing a basis for development of the compound as a novel chemotherapeutic agent. | |
| Cell line/ mice model | MCF-7, MDA-MB-231, MDA-MB-453, MDA-MB-468, MCF-10A | |
| Additional information | It also activated autophagy, as indicated by the triggered autophagosome formation and increased LC3-II levels. Autophagy inhibition by 3-MA co-treatment undermined Jatamanvaltrate P-induced cell death. Valeriana jatamansi Jones (V. jatamansi) belongs to the genus Valeriana of the Valerianaceae family, which is a medicinal plant traditionally used as sedative to treat nervous disorders and epilepsy, as well as a detoxicant, antispasmodic, and carminative agent. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:60458931-2 | |
| Safety | Finally, Jatamanvaltrate P exhibited a potential antitumor effect in MDA-MB-231 xenografts without apparent toxicity. |