| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-127 | |
| Phytochemical name or plant extracts | Jaceosidin | |
| PMID | 32924593 | |
| Literature evidence | Jaceosidin treatment induced a significant (p < 0.05) dose-dependent increase in apoptosis of MCF-7 cells. Jaceosidin similarly modulated the expressions of apoptosis-associated proteins, and revealing a coaction between Bax and Bcl-2, striking a balance between cell survival/cell deaths. | |
| IUPAC name | 5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxychromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Centaurea diluta Artemisia artica | |
| Geographical availability | Centaurea diluta - Algeria, Azores, Canary Is., Madeira, Morocco, Spain, Tunisia Artemisia arctica - Alaska, Alberta, Aleutian Is., British Columbia, California, Colorado, Japan, Kamchatka, Khabarovsk, Kuril Is., Magadan, Montana, Primorye, Sakhalin, Utah, Washington, Wyoming, Yakutskiya, Yukon | |
| Plant parts | Centaurea diluta - Leaves and Flowers Artemisia artica - Herbs | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | ERK and p38 MAPK pathways | |
| IC50 | NA | |
| Potency | Thus, this study demonstrates that jaceosidin could be used as a potential treatment for breast cancer. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | JAS is known to play several pharmacological functions such as antimutagenic, angiogenesis, anti-adipogenic, immunosuppressive, anticancer, antioxidant, anti-inflammatory properties. | |
| PubChem ID | 5379096 | |
| Additional PMIDs | 25295671 27262066 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:190371-1 https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:179216-1 | |
| Safety | NA |