| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1613 | |
| Phytochemical name or plant extracts | Jacein | |
| PMID | 34567171 | |
| Literature evidence | In MTT assay, compounds 1-2 showed cytotoxicity activity against MCF-7 (A) and MDA-MB cells (B) with IC50 values (μM) of 1) 60.04 ± 7.98 (A), and > 200 (B), 2) 42.89 ± 1.91 (A), and 85.31 ± 2.68 (B). | |
| IUPAC name | 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,6-dimethoxy-7-[(2S,4S,5S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Centaurea schmidii | |
| Geographical availability | Iran | |
| Plant parts | Aerial parts | |
| Other cancers | Breast cancer | |
| Target gene or protein | XBP1, sXBP1, ATF-4, ChoP | |
| Gene or Protein evidence | Jacein and 3-demethyljacein from C. schmidii induced ER stress related apoptotic cell death by increasing protein aggregation as demonstrated by fluorescence microscopy analysis and by the marked increase in gene expression of XBP1, sXBP1, ATF-4, and ChoP proteins. I | |
| Target pathways | AMPK/mTOR pathway | |
| IC50 | 60.04 ± 7.98 μM against MCF-7 > 200 μM against MDA-MB 231 | |
| Potency | NA | |
| Cell line/ mice model | MCF-7 and MDA-MB 231 | |
| Additional information | NA | |
| PubChem ID | 44259819 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:191535-1 | |
| Safety | NA |