| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1839 | |
| Phytochemical name or plant extracts | Isoxanthohumol | |
| PMID | 25044854 | |
| Literature evidence | METHODS AND RESULTS: ABCG2-inhibitory activity of xanthohumol (XN), isoxanthohumol (IX), 6-prenylnaringenin (6-PN), 8-prenylnaringenin (8-PN), and 6,8-diprenylnarigenin (6,8-diPN) was evaluated using mitoxantrone accumulation and vesicular transport assays. | |
| IUPAC name | 7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Humulus lupulus | |
| Geographical availability | Alberta, Connecticut, Delaware, Illinois, Indiana, Iowa, Kansas, Kentucky, Maine, Manitoba, Maryland, Massachusetts, Michigan, Minnesota, Montana, Nebraska, New Brunswick, New Hampshire, New Jersey, New York, Newfoundland, North Dakota, Nova Scotia, Ohio, Ontario, Pennsylvania, Prince Edward I., Québec, Rhode I., Saskatchewan, South Dakota, Vermont, Virginia, West Virginia, Wisconsin | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Prostate cancer, Colon cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | In a screening program of natural compounds from fungi inhibiting the TGF-β dependent expression of a reporter gene in HepG2 cells, we found that the flavone isoxanthohumol inhibited the binding of the activated Smad2/3 transcription factors to the DNA and antagonized the cellular effects of TGF-β including reporter gene activation and expression of TGF-β induced genes in HepG2 and MDA-MB-231 cells. | |
| IC50 | NA | |
| Potency | Isoxanthohumol was more potent than cisplatin against breast cancer cell lines MDA-MB-231 and T-47D whereas 6-prenylnaringenin was stronger than cisplatin against breast cancer cell line T-47D. | |
| Cell line/ mice model | MDA-MB-231, T-47D, PC-3, HT-29, A-2780 | |
| Additional information | NA | |
| PubChem ID | 513197 | |
| Additional PMIDs | 30423918 21340508 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:854179-1 | |
| Safety | NA |