| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-394 | |
| Phytochemical name or plant extracts | Isothymusin | |
| PMID | 32648844 | |
| Literature evidence | Therefore, target specific search of novel entities is constant. | |
| IUPAC name | 5,8-dihydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxychromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Ocimum tenuiflorum | |
| Geographical availability | Andaman Is., Assam, Bangladesh, Bismarck Archipelago, Borneo, Cambodia, Caroline Is., China South-Central, China Southeast, East Himalaya, Hainan, India, Jawa, Laos, Lesser Sunda Is., Malaya, Maluku, Marianas, Marshall Is., Myanmar, Nepal, New Guinea, Nicobar Is., Pakistan, Philippines, Queensland, Solomon Is., South China Sea, Sri Lanka, Sulawesi, Sumatera, Taiwan, Thailand, Vanuatu, Vietnam, West Himalaya | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Leukemia, Colon cancer, Skin cancer | |
| Target gene or protein | COX- 2, 5-LOX, CatD, DHFR, hyaluronidase, ODC1 | |
| Gene or Protein evidence | Isothymusin inhibited the enzymes associated with the promotion stage of cancer, including cycloxygenase- 2 and lipoxygenase-5. Additionally, it also inhibited the activity of proliferation markers like cathepsin- D, dihydrofolate reductase, hyaluronidase, and ornithine-decarboxylase. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | NA | |
| Additional information | Isothymusin scavenges the radicals, i.e., DPPH and nitric oxide with moderate ferric reducing potential. It affected the proliferation of leukemia, colon, skin, and breast cancer cell lines by more than 50% but moderately affected prostate, kidney, lung, hepatic, and breast adenocarcinoma (up to 48%). | |
| PubChem ID | 630253 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:453130-1 | |
| Safety | Toxicity studies showed promising results of chemical descriptors and non-skin-irritant, moderate ocular-irritancy, and in vitro Ames test confirmed non-mutagenic nature. |