| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-93 | |
| Phytochemical name or plant extracts | Isoscopoletin | |
| PMID | 24647035 | |
| Literature evidence | These active compounds might be promising lead compounds for the treatment of cancer. | |
| IUPAC name | 6-hydroxy-7-methoxychromen-2-one | |
| Phytochemicals’ class or type of plant extracts | Coumarin | |
| Source of phytochemicals or plant Extracts | Dryopteris fragrans | |
| Geographical availability | Alaska, Alberta, Altay, Amur, British Columbia, Buryatiya, China North-Central, Chita, Finland, Greenland, Inner Mongolia, Irkutsk, Japan, Kamchatka, Khabarovsk, Korea, Krasnoyarsk, Labrador, Magadan, Maine, Manchuria, Manitoba, Michigan, Minnesota, Mongolia, New Brunswick, New Hampshire, New York, Newfoundland, North European Russi, Northwest Territorie, Nova Scotia, Ontario, Primorye, Québec, Sakhalin, Saskatchewan, Tuva, Vermont, West Siberia, Wisconsin, Xinjiang, Yakutskiya, Yukon | |
| Plant parts | Whole plant | |
| Other cancers | Breast cancer, Lung cancer, Liver cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 8.58 ± 1.34 μM against MCF-7 | |
| Potency | Compounds 2, 3, 8 and 9 showed significantly cytotoxic effects against three cell lines (A549, MCF7 and HepG2), 1 and 5 against two cell lines (A549 and MCF7), and 6 against one cell line (MCF7). Compound 3 is Isoscopoletin. | |
| Cell line/ mice model | A549, MCF-7, HepG2 | |
| Additional information | NA | |
| PubChem ID | 69894 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:17095220-1 | |
| Safety | NA |