| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-166 | |
| Phytochemical name or plant extracts | Isorhamnetin | |
| PMID | 30050147 | |
| Literature evidence | Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kγ mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway in human breast cancer cells. | |
| IUPAC name | 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)chromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Tephroseris kirilowii | |
| Geographical availability | Altay, Amur, China North-Central, China South-Central, China Southeast, Chita, Inner Mongolia, Irkutsk, Japan, Khabarovsk, Korea, Manchuria, Mongolia, Primorye, Taiwan, West Siberia, Yakutskiya | |
| Plant parts | Whole plant | |
| Other cancers | Breast cancer | |
| Target gene or protein | MMP2, MMP9, p38 MAPK, STAT-3 | |
| Gene or Protein evidence | Taken together, these data demonstrated that isorhamnetin could significantly inhibit the invasion of MDA-MB-231 cells by downregulating the expression and activity of MMP-2 and MMP-9, which was potentially associated with the suppression of p38 MAPK and STAT3. | |
| Target pathways | PI3K/AKT/mTOR/p70S6K/ULK signaling pathway PI3K/Akt and NF- κ B Pathways | |
| IC50 | NA | |
| Potency | Importantly, treatment with these flavonoids decreased the levels of PI3Kγ-p110, phospho-PI3K, phospho-AKT, phospho-mTOR, phospho-p70S6K, and phospho-ULK. Pretreatment with PI3Kγ specific inhibitor AS605240 potentiated flavonoids-mediated inactivation of AKT, mTOR, p70S6K, ULK, and apoptosis. | |
| Cell line/ mice model | B16F10, MCF-7, MDA-MB-231 | |
| Additional information | The examination on molecular mechanism revealed that IH could suppress the phosphorylation of Akt and the translocation of NF-κB, which are key factors in apoptosis-related pathways. We also detected that this process was related to the bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases 4 (PFKFB4) by PFKFB4 knockdown experiment. | |
| PubChem ID | 5281654 | |
| Additional PMIDs | 24525098 31185340 34311274 31994149 23819303 23724057 15905060 15925220 16698256 18954533 22838964 28539711 29905475 26359917 32572780 15749994 26909969 30050147 31443364 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:255231-1 | |
| Safety | NA |