| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-785 | |
| Phytochemical name or plant extracts | Isoquercitrin | |
| PMID | 28939230 | |
| Literature evidence | The optimal concentration of DPPH was determined, and six potential antioxidants including 4-hydroxyphenylacetic acid, p-coumaric acid, ferulic acid, quercitrin, astragalin, and quercetin, and three non-antioxidants including benzoic acid, coptisine, and berberine, were successfully screened out and validated by conventional DPPH radical scavenging activity assay. | |
| IUPAC name | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Tetrastigma hemsleyanum | |
| Geographical availability | China South-Central, China Southeast, Taiwan, Tibet | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | LSD1 | |
| Gene or Protein evidence | These findings suggest that natural LSD1 inhibitors, and particularly isoquercitrin, are promising for cancer treatment. | |
| Target pathways | Isoquercitrin induced the expression of key proteins in the mitochondrial-mediated apoptosis pathway and caused apoptosis in LSD1-overexpressing MDA-MB-231 cells via the inhibition of LSD1. | |
| IC50 | NA | |
| Potency | These findings suggest that natural LSD1 inhibitors, and particularly isoquercitrin, are promising for cancer treatment. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | Quercitrin and isoquercitrin both bound Fe2+ ions efficiently to give strong UV absorption around 600 nm | |
| PubChem ID | 5280804 | |
| Additional PMIDs | 30552007 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:767683-1 | |
| Safety | NA |